Ba� a�r�s� tedavisinde botulismus toksini; g�n�m�zdeki uygulamalar ve kan�ta dayal� verilerin derlemesi

Ate�, Ye�im

ISSN : 1300-0012 E-ISSN 2458-9446

Anasayfa | �leti�im | ENG

Cilt: 36 Say�: 2 Y�l: 2024

Son Say� Ar�iv Pop�ler Makaleler Bask�daki Makaleler Online Makale G�nder

Ba� a�r�s� tedavisinde botulismus toksini; g�n�m�zdeki uygulamalar ve kan�ta dayal� verilerin derlemesi [A�r�]

A�r�. 2006; 18(3): 5-11

Ba� a�r�s� tedavisinde botulismus toksini; g�n�m�zdeki uygulamalar ve kan�ta dayal� verilerin derlemesi

Ye�im Ate�
Ankara �niversitesi T�p Fak�ltesi Anesteziyoloji Ve Reanimasyon Anabilim Dal�, Algoloji Bilim Dal�

Botulismus toksini Tip A 15 y�ldan daha uzun s�redir �e�itli primer ba� a�r�s� tiplerinin tedavisi ve profilaksisi amac� ile kullan�lmaktad�r. Bu ajan�n ba� a�r�s� tedavisindeki etki mekanizmas� pek �ok �al��mada incelenmi�tir. Asetil kolin sal�n�m� �zerindeki bilinen etkisine ek olarak bir veya daha fazla say�da a�r� ile ilgili transmitterin sal�n�m�n� bloke ederek antinosiseptif etki g�sterdi�i d��n�lmektedir. Botulinum toksininin primer ba� a�r�lar�ndaki klinik kullan�m�n� inceleyen k�rl� olmayan ilk �al��malar, pozitif sonu�lar vermi�tir, ancak son zamanlarda yap�lan metodoloji a��s�ndan yeterli �al��malar kan�ta dayal� bir yakla��mla incelendi�inde bu ajan�n yayg�n klinik kullan�ma girmesini desteklememektedir. Bu derlemede botulinum toksininin kullan�m�; etki mekanizmas�, enjeksiyon teknikleri ve konu hakk�ndaki kan�ta dayal� veriler �ncelikli olarak incelenmi�tir.

Anahtar Kelimeler: Ba� a�r�s�, botulinum toksini

BOTULINUM TOX�N FOR THE TREATMENT OF HEADACHES: A REV�EW OF CURRENT PRACTICES AND EVIDENCE BASED-DATA

Ye�im Ate�
Associate Professor Of Anesthesiology Ankara University Medical Faculty Department Of Anesthesiology & Reanimation And Algology, Ankara, Turkey

Botulinum toxin type A has been used clinically for the prophylaxis and treatment of various types of primary headache disorders for over 15 years. Several studies have been performed to demonstrate its mechanism of its effect. There is adequate data to support the idea that; beside its well-known effect on acetylcholine release an additional antinociceptive effect related to a possible block in one or more pain transmitters exist. Earlier open-labeled studies investigating the clinical outcome of botulinum toxin in primary headache disorders have come out with positive results on the topic however recent evidence based evaluation of data do not seem to support the widespread clinical use of this agent. In this manuscript use of botulinum toxin is reviewed with special emphasize on its mechanism of effect, injection techniques and recent evidence-based data.

Keywords: Headache, botulinum toxin

Ye�im Ate�. BOTULINUM TOX�N FOR THE TREATMENT OF HEADACHES: A REV�EW OF CURRENT PRACTICES AND EVIDENCE BASED-DATA. A�r�. 2006; 18(3): 5-11

Sorumlu Yazar: Ye�im Ate�, T�rkiye

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