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Volume: 32  Issue: 3  Year: 2020
 

Attention: These articles have been accepted for publication; however, this list does not indicate the order in which articles will be published. As new articles are accepted, the order displayed here will change.

Pain and immun system [Ağrı]
Ağrı. 2004; 16(2): 7-16

Pain and immun system

I. Aydınlı, K. Keskinbora
İstanbul Üniversitesi Cerrahpaşa Tıp Fakültesi, Anesteziyoloji Anabilim Dalı, Ağrı Bilim Dalı, İstanbul, Turkey

Recently, it is suggested that peripheric and central immune activation play primary role in hyperalgesia and allodynia. Non-neuronal cells that are immune cells in the periphery and glia (microglia, astrocyte) within the brain and spinal cord can drive hyperalgesic and allodynic states. Microglia and astrocytes, activated in response to noxious stimuli in the body tissues, in the peripheral nerves and also in the spinal cord, produce and release proteins called proinflammatory cytokines (PIC). Release of PIC from activated glia cause excessive release of excitatory neurotransmitters from synaptic terminals of primary afferent neuron and then spinal cord dorsal horn pain transmission neurons to become so hyperexcitable. However, in addition to this effect, PIC appears to interfere with the functions of the hippocampus that are involved in cognition, memory and mood. So PIC are important mediators of enhanced pain both in the periphery and in the central nervous system. As a new approach, it is important that this sight indicates alteration of targets in pain management.



Ağrı patolojisinde yeni yaklaşım immun sistem-sensoryal sistem etkileşimi

I. Aydınlı, K. Keskinbora
İstanbul Üniversitesi Cerrahpaşa Tıp Fakültesi, Anesteziyoloji Anabilim Dalı, Ağrı Bilim Dalı, İstanbul, Turkey



I. Aydınlı, K. Keskinbora. Pain and immun system. Ağrı. 2004; 16(2): 7-16

Corresponding Author: I. Aydınlı


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