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Volume: 36  Issue: 1   Year: 2023
  Low doses of prazosin potantiates the antinociceptive / analgesic effect of amitriptyline [Ağrı]
Ağrı. 2005; 17(1): 54-56

Low doses of prazosin potantiates the antinociceptive / analgesic effect of amitriptyline

Murat Büyükşekerci, Hülya Gültekin
Erciyes University Medical Faculty, Department Of Pharmacology, Kayseri, Turkey

In this study, we aimed to reveal the interaction between the tricyclic antidepressant amitriptyline and a1-adrenoceptor antagonist prazosin in mice by using an analgesiometric device hot-plate. Amitriptyline (10 mg/kg) has analgesic effect as expected. Neither of the prazosin doses (0.1, 0.2, 0.5, 1 mg/kg) displayed analgesic effect alone. The combination of lower doses of prazosin (0.1, 0.2, 0.5 mg/kg) with amitriptyline (10 mg/kg) potentiated the antinociceptive effect of this drug. However, the relatively higher dose of prazosin (1 mg/kg) did not effect amitriptyline analgesia. Thus we conclude that the antinociceptive effect of amitriptyline is potentiated by low doses of prazosin.



Düşük doz prazosin amitriptilin’in antinosiseptif / analjezik etkisini potansiyalize ediyor

Murat Büyükşekerci, Hülya Gültekin
Erciyes University Medical Faculty, Department Of Pharmacology, Kayseri, Turkey



Murat Büyükşekerci, Hülya Gültekin. Low doses of prazosin potantiates the antinociceptive / analgesic effect of amitriptyline. Ağrı. 2005; 17(1): 54-56

Corresponding Author: Murat Büyükşekerci


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