ISSN : 1300-0012   E-ISSN 2458-9446 Home      |      Contact      |      TR
 
 
Volume: 36  Issue: 1   Year: 2023
  Maximizing Value in Opioid Utilization: Is Oxycodone Immediate Release a Good Option for Pain Management? [Ağrı]
Ağrı. 2015; 27(1): 1-11 | DOI: 10.5505/agri.2015.79663  

Maximizing Value in Opioid Utilization: Is Oxycodone Immediate Release a Good Option for Pain Management?

Joseph V Pergolizzi1, Gül Köknel Talu2, Gianpetrio Zmponga3, Serdar Erdine2, Robert Taylor3, Burak Ayan4, Robert B Raffa5
1Department Of Medicine, Johns Hopkins University School Of Medicine, Baltimore; Department Of Pharmacology, Temple University School Of Medicine, Philadelphia, Pa; Nema Research Inc, Bonita Springs, Fl, Usa
2Department Of Algology, Medical Faculty Of Istanbul, Istanbul University, Turkey
3Nema Research Inc, Bonita Springs, Fl, Usa
4Bahçelievler State Hospital, Istanbul, Turkey
5Department Of Pharmaceutical Sciences, Temple University School Of Pharmacy, Philadelphia, Pa, Usa

The modern approach to the management of pain involves optimizing all aspects of the process. This includes utilization of pharmacologic and non-pharmacologic modalities, consideration of patient characteristics, proper matching of the physiology of the pain with the analgesic’s mechanism of action (pharmacodynamics, PD), and the onset and duration of action (pharmacokinetics, PK). No single agent or formulation satisfies all of the requirements for all patients. Aspirin and other non-steroidal anti-inflammatory drugs (NSAIDs) are effective options for inflammatory pain and, as is acetaminophen, for mild pain. Specialized agents are helpful for particular pains, such as for migraine headache. Opioids remain the standard option for severe pain. Although they are generally a safe and effective option, opioids can produce dose-limiting adverse effects and have abuse potential. The goal of pain therapy is thus to achieve the maximum pain relief with the least amount of opioid exposure. Against this background of measured approach to the use of analgesics, an immediate release (IR) oral formulation of the established opioid oxycodone has been developed to provide rapid onset of action and rate of titration, both of which could maximize temporal matching of dose with pain level and reduce total exposure to drug. This article considers the option of an immediate release (IR) oral formulation for the management of pain.

Keywords: Opioid, oxycodone; pain management.


Opiyoit kullanımının değerini maksimize etmek: Hızlı salımlı oksikodon ağrı tedavisinde iyi bir seçenek midir?

Joseph V Pergolizzi1, Gül Köknel Talu2, Gianpetrio Zmponga3, Serdar Erdine2, Robert Taylor3, Burak Ayan4, Robert B Raffa5
1Johns Hopkins Üniversitesi Tıp Fakültesi, Tıp Anabilim Dalı, Baltimore; Temple Üniversitesi Tıp Fakültesi, Farmakoloji Anabilim Dalı, Philadelphia, Pa; Nema Araştırma Aş, Banita Springs, Fl, Abd
2İstanbul Üniversitesi İstanbul Tıp Fakültesi, Algoloji Anabilim Dalı, İstanbul, Türkiye
3Nema Araştırma Aş, Banita Springs, Fl, Abd
4Bahçelievler Devlet Hastanesi, İstanbul, Türkiye
5Temple Üniversitesi Eczacılık Fakültesi, Eczacılık Bilimleri Bölümü, Philadelphia, Pa, Abd

The modern approach to the management of pain involves optimizing all aspects of the process. This includes utilization of pharmacologic and non-pharmacologic modalities, consideration of patient characteristics, proper matching of the physiology of the pain with the analgesic’s mechanism of action (pharmacodynamics, PD), and the onset and duration of action (pharmacokinetics, PK). No single agent or formulation satisfies all of the requirements for all patients. Aspirin and other non-steroidal anti-inflammatory drugs (NDAIDs) are effective options for inflammatory pain and, as is acetaminophen, for mild pain. Specialized agents are helpful for particular pains, such as for migraine headache. Opioids remain the standard option for severe pain. Although they are generally a safe and effective option, opioids can produce dose-limiting adverse effects and have abuse potential. The goal of pain therapy is thus to achieve the maximum pain relief with the least amount of opioid exposure. Against this background of measured approach to the use of analgesics, an immediate release (IR) oral formulation of the established opioid oxycodone has been developed to provide rapid onset of action and rate of titration, both of which could maximize temporal matching of dose with pain level and reduce total exposure to drug. This article considers the option of an immediate release (IR) oral formulation for the management of pain.

Anahtar Kelimeler: Opioid, oksikodin; ağrı yönetimi.


Joseph V Pergolizzi, Gül Köknel Talu, Gianpetrio Zmponga, Serdar Erdine, Robert Taylor, Burak Ayan, Robert B Raffa. Maximizing Value in Opioid Utilization: Is Oxycodone Immediate Release a Good Option for Pain Management?. Ağrı. 2015; 27(1): 1-11

Corresponding Author: Robert Taylor, United States


TOOLS
Full Text PDF
Print
Download citation
RIS
EndNote
BibTex
Medlars
Procite
Reference Manager
Share with email
Share
Send email to author

Similar articles
PubMed
Google Scholar




   
Copyright © 2024 The Journal of The Turkish Society of Algology, All Rights Reserved.