Reliability and Validity of Turkish Version of Migraine-Specific Quality of Life v2.1 Questionnaire
Pinar Yalinay Dikmen1, Aysenur Sahin1, Elif Ilgaz Aydinlar1, Tuba Erdogan Soyukibar1, Aynur Özge2, Rahsan Karaci3, Burcu Polat4, Tuba Cerrahoglu Sirin5, Damla Hazal Saral6, Bahar Tasdelen61Acibadem University, School Of Medicine, Department Of Neurology, Istanbul, Turkey2Mersin University Faculty Of Medicine, Department Of Neurology, Mersin, Turkey
3University Of Health Sciences Erenköy Psychiatry And Neurological Diseases Training And Research Hospital, Department Of Neurology, Istanbul, Turkey
4Duzce University, School Of Medicine, Department Of Neurology, Duzce, Turkey
5University Of Health Sciences, Sisli Hamidiye Etfal Training And Research Hospital, Department Of Neurology, Istanbul, Turkey
6Mersin University Faculty Of Medicine, Department Of Biostatistics And Medical Informatics, Mersin University, Mersin, Turkey
Background: This study aimed to assess whether the Turkish version of the Migraine-Specific Quality of Life Questionnaire v2.1 (MSQ v2.1) is a reliable and valid tool for evaluating the impact of migraine on daily functioning and overall quality of life.
Methods: A multicenter, prospective, descriptive study, involving182 migraine patients, each assessed at two visits, four weeks apart. The Turkish MSQ v2.1 was evaluated for comprehensibility, patient-physician reliability, internal consistency, test-retest reliability, and construct validity.
Results: Item comprehensibility was high, with 94% to 97.8% at Visit 1, and from 98.4% to 100% at Visit 2. A strong correlation was observed between self-administered and physician-administered MSQ v2.1 scores at Visit 1 (R = 0.916, p < 0.001). Internal consistency was excellent, with Cronbach’s alpha values of 0.932 at Visit 1 and 0.912 at Visit 2. Test-retest reliability was moderate (R = 0.468, p < 0.001). Construct validity was supported by strong correlations with the Headache Impact Test-6 (HIT-6) (R = 0.751 at Visit 1 and R = 0.772 at Visit 2), monthly headache days (MHDs) (R = 0.453 and 0.553), and Numeric Rating Scale (NRS) scores (R = 0.539 and 0.564), all with p < 0.001.
Conclusions: The Turkish MSQ v2.1 is a reliable and valid tool for assessing health-related quality of life (HRQL) in migraine patients. It demonstrates excellent internal consistency, moderate test-retest reliability, and strong correlations with established measures of HRQL, headache severity, migraine frequency, and supporting its use in clinical practice and research.
Keywords: Migraine, Migraine-Specific Quality of Life Questionnaire (MSQ), Health-Related Quality of Life (HRQoL), Reliability, Validity; Clinical Scale
Manuscript Language: English