Objective: The aim of this study was to compare the pre-emptive analgesic efficacy of intravenous (IV) dexketoprofen trometamol (DT) and placebo, following impacted mandibular third molar surgery.
Methods: Twenty patients over 18 year old who needed bilateral lower third molar extractions were included in this prospective, randomized and placebo-controlled clinical trial. Patients whom had taken DT 50 mg of before their one extraction, took placebo before their other extraction which had been performed on the opposite side. A total of 40 observations were made. Pain scores were evaluated with a Verbal Rating Scale (VRS) after surgery. Moreover; the time to first analgesic requirement use, additional analgesic need of patients, patient and doctor satisfaction, side effects were also determined.
Results: During the first 12 hours, the VRS values in DT group were significantly lower than those of placebo group patients (p<0.05). In placebo group, the time to first analgesic requirement use was significantly earlier than that of patients in DT group (p<0.05). Additional analgesic need of placebo group were significantly greater, when compared with the analgesic need of DT group patients (p<0.05). Among the DT group patients, patient and physician satisfaction was greater, which was statistically significant (p<0.05).
Conclusion: Preemptive use of IV DT is more effective than placebo for using as preemptive analgesia for acute postoperative pain control in patients underwent removal of an impacted mandibular third molar surgery.
Giriş: Bu çalışmada, intravenöz (IV) deksketoprofen trometamol’ün (DT) gömük üçüncü molar diş cerrahisindeki preemptif analjezik etkinliğinin plasebo grubuyla karşılaştırılması amaçlandı.
Materyal-metot: Bilateral gömük diş çekimi yapılacak 18 yaş üzerinde 20 hasta prospektif, randomize, plasebo kontrollu çalışmaya dahil edildi. Bir diş çekiminde 50 mg DT alan hastaya diğer diş çekiminde plasebo uygulandı.Toplam 40 gözlem yapıldı. Ağrı skorları cerrahi sonrası Sözel Ağrı Skalası (VRS) ile değerlendirildi. Ayrıca ilk analjezik alma zamanı, ek analjezik ihtiyacı olan hastalar, hasta ve hekim memnuniyeti, yan etkiler kaydedildi.
Bulgular: İlk 12 saat içinde VRS skoru DT grubunda plasebo grubuna göre anlamlı olarak daha düşüktü. (p<0.05). İlk analjezik ihtiyacı plasebo grubunda DT grubuna oranla istatistiksel olarak anlamlı daha erken oldu (p<0.05). Plasebo grubundaki hastaların ek analjezik ihtiyacı DT alan hastalara oranla istatistiksel olarak anlamlı daha fazlaydı (p<0.05). DT grubunda hasta ve hekim memnuniyeti istatistiksel olarak daha fazlaydı (p<0.05).
Sonuç: Üçüncü molar diş cerrahisinde preemptif IV DT kullanımının plaseboya oranla çok daha etkin postoperatif analjezi sağladığını saptadık.