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Volume: 34  Issue: 4   Year: 2022
  The comparison of the effects and side effects of local anesthetic and opioid combinations in epidural patient controlled analgesia [Ağrı]
Ağrı. 2005; 17(2): 34-39

The comparison of the effects and side effects of local anesthetic and opioid combinations in epidural patient controlled analgesia

Zeynep Eti1, Tümay Umuroğlu1, Arzu Takıl1, Yılmaz Göğüş1
Marmara University Faculty of Medicine, Department of Anesthesiology, İstanbul, Turkey

The aim of this study was to retrospectively evaluate the efficacy and side effects of local anesthetic and opioid combinations in 457 patients who have received epidural patient-controlled analgesia (EPCA). Hemodynamic parameters, numeric rating scale, sedation scores, the degree of motor and sensory blockage, the presence of side effects, the parameters of PCA device were recorded from the postoperative pain records. 253 patients received 0.1 % bupivacaine + 3 µg/ml fentanyl (Group B1F3), 80 patients received 0.125 % bupivacaine + 3 µg/ml fentanyl (Group B12F3), 43 patients received 0.125 % bupivacaine + 4 µg/ml fentanyl (Group B12F4), 46 patients received 0.1 % bupivacaine + 0.1 mg/ml morphine (Group B1M1) and 35 patients received 0.125 % bupivacaine + 0.1 mg/ml morphine (Group B12M1). Nausea was significantly higher in group B1M1 compared to B12F3, in group B12M1 compared to B1F3 and B12F3 (p<0.05), vomiting was significantly higher in group B1M1 and B12M1 (p<0.05) compared to B12F3, pruritus was significantly higher in group B12F4 compared to B12F3 and B1F3, in group B1M1 compared to B1F3 and B12F3 and in group B12M1 compared to B1F3 and B12F3 (p<0.05). As a result, in EPCA, the combination of bupivacaine and fentanyl provides as effective analgesia as the combination of bupivacaine and morphine and 3 mg/ml fentanyl admixture may be preferred with less side effects such as nausea, vomiting and pruritus.



Epidural hasta kontrollü analjezi yönteminde lokal anestezik - opioid birlikteliğinin etkinlik ve yan etkilerinin araştırılması

Zeynep Eti1, Tümay Umuroğlu1, Arzu Takıl1, Yılmaz Göğüş1
Marmara University Faculty of Medicine, Department of Anesthesiology, İstanbul, Turkey



Zeynep Eti, Tümay Umuroğlu, Arzu Takıl, Yılmaz Göğüş. The comparison of the effects and side effects of local anesthetic and opioid combinations in epidural patient controlled analgesia. Ağrı. 2005; 17(2): 34-39


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