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Volume: 33  Issue: 3  Year: 2020
  Dexketoprofen for Postoperative Pain Relief. [Ağrı]
Ağrı. 2006; 18(3): 30-35

Dexketoprofen for Postoperative Pain Relief.

Sema Tuncer1, Aybars Tavlan2, Hatice Köstekçi2, Ruhiye Reisli1, Şeref Otelcioğlu2
1Selcuk University Meram Faculty of Medicine, Department of Algology,Konya
2Selcuk University Meram Faculty of Medicine, Department of Anesthesiology, Konya

Dexketoprofen trometamol is a water-soluble salt of the dextrorotatory enantiomer of nonsteroidal anti-inflamatory drug ketoprofen. The aim of the study was to investigate the effect of dexketoprofen on postoperative pain. This study was performed on 50 (ASA I-II) patients planned for abdominal hysterectomy. Fifty patients were randomized into two equal groups. Patients received oral placebo (group I) and 25 mg dexketoprofen (group II) 1h before surgery and 8 -16 h after surgery. All patients received a standard anesthetic protocol. At the end of surgery, all patients received tramadol IV via a PCA (Patient Controlled Analgesia) -device. Pain scores and sedation scores were assessed at 3,6,12 and 24 h after surgery. Tramadol consumption, adverse effects, and patient satisfaction were noted during 24 h after the surgery. The pain scores were significantly lower in the dexketoprofen group compared with the placebo group (p<0.05). The cumulative tramadol consumption was lower in the dexketoprofen group than placebo group (p<0.05). No significant difference was observed in sedation scores, adverse effects and patient satisfaction between the groups (p>0.05). We conclude that the preoperative and postoperative administration of dexketoprofen provided a significant analgesic benefit and decreased the opioid requirements in patients undergoing abdominal hysterectomy.

Keywords: Dexketoprofen, tramadol, postoperative pain, PCA, abdominal hysterectomy


Postoperatif Ağrıda Deksketoprofen Kullanımı

Sema Tuncer1, Aybars Tavlan2, Hatice Köstekçi2, Ruhiye Reisli1, Şeref Otelcioğlu2
1Selçuk Üniversitesi Meram Tıp Fakültesi, Algoloji Bilim Dalı, Konya
2Selçuk Üniversitesi Meram Tıp Fakültesi,Anesteziyoloji ve Reanimasyon Anabilim Dalı, Konya

Deksketoprofen trometamol nonsteroid antiiinflamatuar bir ajan olan ketoprofenin aktif enantiomeridir. Bu çalışmada postoperatif analjezide dexketoprofenin etkinliğini değerlendirmeyi amaçladık. Abdominal histerektomi planlanan ASA I-II grubu 50 olgu çalışmaya alındı ve randomize olarak 2 gruba ayrıldı. Operasyondan 1 saat önce ve operasyondan sonra 8. ve 16. saatlerde grup I’e oral plasebo, grup II’ye 25 mg deksketoprofen verildi. Bütün olgulara standart genel anestezi uygulandı. Cerrahinin sonunda olgulara IV Hasta kontrollü analjezi (HKA) cihazı ile tramadol uygulandı. Ağrı ve sedasyon skorları 3,6,12 ve 24.saatlerde değerlendirildi. Çalışma sonunda tramadol tüketimi, yan etkiler ve hasta memnuniyeti kaydedildi. Ağrı skorları ve tramadol tüketimi deksketoprofen grubunda daha düşük bulundu (p<0.05). Sedasyon skorları, yan etkiler ve hasta memnuniyeti gruplar arasında benzer bulundu (p>0.05). Sonuç olarak, abdominal histerektomi operasyonlarında preoperatif ve postoperatif uygulanan deksketoprofen, opioid ihtiyacını azaltmakta ve analjezik etki sağlamaktadır.

Anahtar Kelimeler: Deksketoprofen, tramadol, postoperatif ağrı, HKA, abdominal histerektomi


Sema Tuncer, Aybars Tavlan, Hatice Köstekçi, Ruhiye Reisli, Şeref Otelcioğlu. Dexketoprofen for Postoperative Pain Relief.. Ağrı. 2006; 18(3): 30-35

Corresponding Author: Sema Tuncer, Türkiye


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