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Volume: 32  Issue: 4  Year: 2020
 

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The effects of intravenous paracetamol on postoperative analgesia and tramadol consumption in cesarean operations [Ağrı]
Ağrı. 2010; 22(1): 7-12

The effects of intravenous paracetamol on postoperative analgesia and tramadol consumption in cesarean operations

Alper Kılıçaslan1, Sema Tuncer2, Ali Yüceaktaş1, Mehmet Uyar3, Ruhiye Reisli2
1Departments Of Anesthesiology, Selcuk University Meram Faculty Of Medicine, Konya, Turkey
2Departments Of Algology, Selcuk University Meram Faculty Of Medicine, Konya, Turkey
3Departments Of Public Health, Selcuk University Meram Faculty Of Medicine, Konya, Turkey

Objectives: In this study, the effects and side effects of intravenous paracetamol application, combined with patient-controlled intravenous tramadol analgesia, were investigated in elective cesarean operations for postoperative pain control and its tramadol-sparing effect. Methods: Fifty ASA I-II patients scheduled for cesarean operation were enrolled in this study. Patients were randomly divided into two groups: group I served as a control group, with saline administration (100 ml) 15 min before the end surgery and every 6 h for 24 h, whereas group II received paracetamol (1 g/100 ml) at the stated time points. All patients received a standard anesthetic protocol. At the end of surgery, all patients received tramadol i.v. via a PCA (patient-controlled analgesia) device. Pain and sedation scores were assessed at 1, 3, 6, 12 and 24 h postoperatively.
Results: Tramadol consumption and adverse effects were noted in the first 24 hours following surgery. The pain scores were significantly lower in the paracetamol group when compared with the control group (p<0.05). The cumulative tramadol consumption was lower in the paracetamol group than the control group (p<0.05). No significant difference was observed in sedation scores and nausea-vomiting scores between the groups (p>0.05). Conclusion: We conclude that paracetamol is a safe and effective treatment option in post-cesarean pain for combination with tramadol, as it produces effective analgesia and reduces tramadol consumption.

Keywords: Paracetamol, postoperative analgesia; cesarean; tramadol


Sezaryen cerrahisinde intravenöz parasetamolün postoperatif analjezi ve tramadol tüketimine etkisi

Alper Kılıçaslan1, Sema Tuncer2, Ali Yüceaktaş1, Mehmet Uyar3, Ruhiye Reisli2
1Selçuk Üniversitesi Meram Tıp Fakültesi, 1anesteziyoloji Ve Reanimasyon Anabilim Dalı, Konya
2Selçuk Üniversitesi Meram Tıp Fakültesi, Algoloji Bilim Dalı, Konya
3Selçuk Üniversitesi Meram Tıp Fakültesi, Halk Sağlığı Anabilim Dalı, Konya

Amaç: Bu çalışmada, sezaryen operasyonlarında hasta kontrollü analjezide (HKA) intravenöz (iv) tramadol ile kombine edilen iv parasetamolün postoperatif ağrı kontrolü ve tramadol kullanımı ve yan etkileri araştırıldı. Gereç ve Yöntem: Sezaryen operasyonu geçirecek ASA I-II grubu 50 hasta çalışmaya dahil edildi. Hastalar randomize olarak iki gruba ayrıldı ve bütün olgulara standart genel anestezi uygulandı. Grup I’e operasyon sonlanmadan 15 dk önce ve operasyon sonrası 6 saat ara ile 100 cc serum fizyolojik, grup II’ye ise aynı zaman aralıklarında 1gr iv parasetamol ilk 24 saat verildi. Cerrahinin sonunda olgulara iv HKA cihazı ile tramadol uygulandı. Ağrı ve sedasyon skorları 1., 3., 6., 12. ve 24. saatlerde değerlendirildi. Bulgular: Çalışma sonunda tramadol tüketimi ve yan etkiler kaydedildi. Ağrı skorları ve tramadol tüketimi parasetamol grubunda, kontrol grubuna göre daha düşük bulundu (p<0.05). Sedasyon skorları ve bulantı-kusma gruplar arasında benzer bulundu (p>0.05). Sonuç: Sonuç olarak sezaryen operasyonları sonrası tramadol ile birlikte kullanılan parasetamol güvenilir ve etkin bir analjezi sağlamakta, tramadol tüketimini azaltmaktadır.

Anahtar Kelimeler: Parasetamol, postoperatif analjezi; sezaryen; tramadol


Alper Kılıçaslan, Sema Tuncer, Ali Yüceaktaş, Mehmet Uyar, Ruhiye Reisli. The effects of intravenous paracetamol on postoperative analgesia and tramadol consumption in cesarean operations. Ağrı. 2010; 22(1): 7-12

Corresponding Author: Sema Tuncer, Türkiye


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