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Volume: 32  Issue: 3  Year: 2020
 

Attention: These articles have been accepted for publication; however, this list does not indicate the order in which articles will be published. As new articles are accepted, the order displayed here will change.

The analgesic and anti-inflammatory effects of subcutaneous bupivacaine, morphine and tramadol in rats [Ağrı]
Ağrı. 2004; 16(3): 53-58

The analgesic and anti-inflammatory effects of subcutaneous bupivacaine, morphine and tramadol in rats

Arzu Gerçek1, Zeynep Eti1, F. Yılmaz Göğüş1, Aydın Sav2
1Marmara University School Of Medicine, Department Of Anesthesiology And Reanimation, İstanbul, Turkey
2Marmara University School Of Medicine, Department Of Pathology, İstanbul, Turkey

The analgesic and anti-inflammatory effects of subcutaneously administered bupivacaine, morphine and tramadol on formalin-induced inflammation were compared. 0.25 % bupivacaine in Group B, 20 mg/kg tramadol in Group T, 1 mg/kg morphine in Group M and 0.9 % NaCl in Group S in a volume of 200 µl were injected into the right hind paw of the rats (n: 40) 15 minutes before injection of 50 µl 5 % formalin. Sedation and pain behaviour scores, number of flinches and licking-time were recorded. The degree of dermal edema, intraneural edema, vasodilation, erythrodiapedesis, infiltration of polymorphonuclear leukocyte/lymphocyte and mast cell counts were analyzed histopathologically. In Group T and B, circumferential changes were lower than in Group M and S. The pain behaviour scores were significantly lower in Group T and B. The number of flinches in Group T was lower than Group B and S. The vasodilation was significant only in Group M. The dermal edema was limited to deep dermis only in Group T. Preinflammational subcutaneous tramadol infiltration can provide effective analgesia and may have anti-inflammatory effects.



Arzu Gerçek, Zeynep Eti, F. Yılmaz Göğüş, Aydın Sav. The analgesic and anti-inflammatory effects of subcutaneous bupivacaine, morphine and tramadol in rats. Ağrı. 2004; 16(3): 53-58

Corresponding Author: Arzu Gerçek


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