Ağrı. 2001; 13(1): 39-43

The antinociceptive effects of intraperitoneal administration of central acting drugs in mice

O. N. Aydın¹, A. Erenmemişoğlu^2
1Adnan Menderes University, Faculty of Medicine, Department of Anesthesiology, Assistant Professor
²Erciyes University, Faculty of Medicine, Department of Pharmacology, Associate Professor

The antinociceptive effects of intraperitoneal injection of central acting drugs on tail-flick response of the mice were determined. This study was performed after the approval of Adnan Menderes University Laboratory Animals Ethics Committee. Initially, weight of mice were measured and their tail flick responses were recorded. Twenty-four hours later, diazepam (5 and 50 mg/kg), midazolam (1 and 10 mg/kg), phenytoin (50 mg/kg), biperiden (30 mg/kg), nicotine (5 mg/kg) and atropine (30 mg/kg) were administrated intraperitoneally. The tail-flick latencies were reduced significantly in 5 mg/kg diazepam and 10 mg/kg midazolam injected groups. On the other hand, the tail-flick latencies were increased significantly in diazepam (50 mg/kg), phenytoin, biperiden, and nicotine injected groups. These results suggest that phenytoin, biperiden, and nicotine have antinociceptive and diazepam and midazolam have dose-dependent hyperalgesic effects. In conclusion, hyperalgesic and antinociceptive effects of central acting drugs should be considered when they are combined with analgesic drugs during acute or chronic pain treatment.

Keywords: Antinociception, central acting drugs, intraperitoneal, mice, tail-flick response

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Farelerde intraperitoneal uygulanan santral etkili ilaçların antinosiseptif etkileri

O. N. Aydın¹, A. Erenmemişoğlu^2
1Adnan Menderes University, Faculty of Medicine, Department of Anesthesiology, Assistant Professor
²Erciyes University, Faculty of Medicine, Department of Pharmacology, Associate Professor

Santral etkili ilaçların antinosiseptif etkileri farelerde tail-flick testi ile araştırıldı. Bu çalışma için Adnan Menderes Üniversitesi Hayvan Labaratuvarı Etik Komitesi’nden izin alındı. Farelerin ağırlıkları ve tail-flick testi ile kuyruk çekme süreleri tespit edildi. Yirmidört saat sonra, diazepam (5 ve 50 mg/kg), midazolam (1 ve 10 mg/kg), fenitoin (50 mg/kg), biperiden (30 mg/kg), nikotin (5 mg/kg) ve atropin (30 mg/kg) intraperitoneal yolla uygulandı. 5 mg/kg diazepam ve 10 mg/kg midazolam uygulanan grupta kuyruk çekme süresi anlamlı olarak azaldı. Buna karşın 50 mg/kg diazepam, fenitoin, biperiden ve nikotin uygulanan gruplarda bu süre uzadı. Bu sonuçlar fenitoin, biperiden ve nikotinin antinosiseptif, diazepam ve midazolamın doza bağlı olarak hiperaljezik etkiler gösterdiğini düşündürmektedir. Akut veya kronik ağrı sağaltımında santral etkili ilaçları, analjezik ilaçlarla birlikte kullanırken, hiperaljezik ve antinosiseptif özellikleri gözönünde bulundurulmalıdır

Anahtar Kelimeler: Antinosiseptif etki, santral etkili ilaçlar, intraperitoneal, fare, tail-flick testi.

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