Peripheral and central mechanisms in neuropathic pain

Y�cel, A.

ISSN : 1300-0012 E-ISSN 2458-9446

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Volume: 36 Issue: 2 Year: 2024

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Peripheral and central mechanisms in neuropathic pain [A�r�]

A�r�. 2002; 14(1): 17-22

Peripheral and central mechanisms in neuropathic pain

A. Y�cel¹
�stanbul �niversitesi �stanbul T�p Fak�ltesi, Algoloji Bilim Dal�, Prof. Dr.

Painful neuropathic conditions may accompany a lesion or dysfunction of peripheral or central nervous system. Painful neuropathies are caracterized by spontaneous or abnormal stimulus evoked pain. Evoked pain is defined as allodynia when caused by normally innoxious stimuli. Hyperalgesia is defined as increased pain intensity evoked by normally painful stimuli. Painful neuropathies are also often associated with nonpainful abnormal spontaneous or and evoked sensory phenomena such as paresthesia and dysestesia. Several animal and human experimental models demonstrate that neuropathic pain is the culmination of a number of changes in the peripheral nervous system. However, many of the drugs that are effective in patients and in animals have effects through central targets. The ultimate goal is to develop satisfactory, and reliable treatment modalities. Help for neuropathic pain patients will require close cooperation among clinicians and scientists.

Keywords: Neuropathic pain, mechanism, peripheral, central

N�ropatik a�r�da periferik ve santral mekanizmalar

A. Y�cel¹
�stanbul �niversitesi �stanbul T�p Fak�ltesi, Algoloji Bilim Dal�, Prof. Dr.

A�r�l� n�ropatik rahats�zl�klar, periferik veya merkezi sinir sistemindeki bir lezyona ya da disfonksiyona e�lik edebilir. A�r�l� n�rapatilerin karakteristik �zelli�i spontan ya da anormal stimulusla ortaya ��kan a�r�d�r. Hiperaljezi, normalde a�r�l� olan bir uyar�ya cevab�n artmas�d�r. A�r�l� n�ropatiler genellikle parestezi ve dizestezi gibi, spontan veya uyar�yla ortaya ��kan, a�r�s�z sensoryal fenomenlerle ili�kilidir. Baz� deneysel insan ve hayvan modelleri, n�ropatik a�r�n�n, periferik sinir sistemindeki bir dizi de�i�ikli�in son basma�� oldu�unu g�stermektedir. Ancak insanlarda ve hayvanlarda etkili oldu�u g�sterilmi� ila�lar�n bir�o�u etkisini santral mekanizmalarla g�stermektedir. En �nemli ama� g�venilir ve tatmin edici tedavi y�ntemlerini geli�tirmektir. N�ropatik a�r� tedavisindeki geli�meler, temel bilimler ile klinik �al��malar aras�nda kuvvetli i�birli�i kurulmas�na ba�l�d�r.

Anahtar Kelimeler: N�ropatik a�r�, mekanizma, periferik, santral

A. Y�cel. Peripheral and central mechanisms in neuropathic pain. A�r�. 2002; 14(1): 17-22

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