Murat Guntel1, Ozge Hurdogan1, Derya Uluduz2, Taskin Duman1

1Mustafa Kemal University School Of Medicine, Neurology Department, Antakya, Turkey
2Istanbul University Cerrahpasa School Of Medicine Neurology Department, Istanbul, Turkey

Keywords: Primary stabbing headache, primary headache, treatment, indomethacin.

Abstract

Primary stabbing headache is an excruciating and relatively rare type of headache that typically lasts for only a few seconds. Pain is predominantly felt in the distribution of the first division of the trigeminal nerve and can be experienced as single stabs or as a series of stabs, either per day or every few days. Primary stabbing headache has been well-defined for decades and must be kept in mind during diagnosis. Exclusion of other possible causes is necessary in order to establish diagnosis. Indomethacin has classically been considered the first treatment option, but therapeutic failure occurs in up to 35% of cases. Recent studies have suggested that cyclooxygenase-2 inhibitors, gabapentin, nifedipine, paracetamol, and melatonin are also effective treatments.