Düşük doz prazosin amitriptilin’in antinosiseptif / analjezik etkisini potansiyalize ediyor

Murat Büyükşekerci; Hülya Gültekin

Murat Büyükşekerci, Hülya Gültekin

Erciyes University Medical Faculty, Department Of Pharmacology, Kayseri, Turkey

Abstract

In this study, we aimed to reveal the interaction between the tricyclic antidepressant amitriptyline and a1-adrenoceptor antagonist prazosin in mice by using an analgesiometric device hot-plate. Amitriptyline (10 mg/kg) has analgesic effect as expected. Neither of the prazosin doses (0.1, 0.2, 0.5, 1 mg/kg) displayed analgesic effect alone. The combination of lower doses of prazosin (0.1, 0.2, 0.5 mg/kg) with amitriptyline (10 mg/kg) potentiated the antinociceptive effect of this drug. However, the relatively higher dose of prazosin (1 mg/kg) did not effect amitriptyline analgesia. Thus we conclude that the antinociceptive effect of amitriptyline is potentiated by low doses of prazosin.

BibTex	`@article{ agri30, author = {Murat Büyükşekerci, Hülya Gültekin}, title = {Düşük doz prazosin amitriptilin’in antinosiseptif / analjezik etkisini potansiyalize ediyor}, journal = {Agri}, year = {2005}, volume = {17}, number = {1}, pages = {54-56}, publisher = {The Turkish Society of Algology} }`
RIS	`TY - JOUR AU - Murat Büyükşekerci, Hülya Gültekin PY - 2005 TI - Düşük doz prazosin amitriptilin’in antinosiseptif / analjezik etkisini potansiyalize ediyor SP - 54 EP - 56 JO - The Journal of the Turkish Society of Algology J2 - Agri VL - 17 IS - 1 PB - ER -`
EndNote	`%0 Journal Article %A Murat Büyükşekerci, Hülya Gültekin %T Düşük doz prazosin amitriptilin’in antinosiseptif / analjezik etkisini potansiyalize ediyor %J The Journal of the Turkish Society of Algology %D 2005 %V 17 %N 1 %P 54-56`
APA	Murat Büyükşekerci, Hülya Gültekin (2005). Düşük doz prazosin amitriptilin’in antinosiseptif / analjezik etkisini potansiyalize ediyor. The Journal of the Turkish Society of Algology, 17(1), 54-56.
MLA	Murat Büyükşekerci, Hülya Gültekin. "Düşük doz prazosin amitriptilin’in antinosiseptif / analjezik etkisini potansiyalize ediyor" The Journal of the Turkish Society of Algology, vol. 17, no. 1, 2005, pp. 54-56.
Chicago	Murat Büyükşekerci, Hülya Gültekin. "Düşük doz prazosin amitriptilin’in antinosiseptif / analjezik etkisini potansiyalize ediyor" The Journal of the Turkish Society of Algology 17, no. 1 (2005): 54-56.
AMA	Murat Büyükşekerci, Hülya Gültekin. Düşük doz prazosin amitriptilin’in antinosiseptif / analjezik etkisini potansiyalize ediyor. Agri. 2005; 17(1): 54-56.
Vancouver	Murat Büyükşekerci, Hülya Gültekin. Düşük doz prazosin amitriptilin’in antinosiseptif / analjezik etkisini potansiyalize ediyor. Agri. 2005; 17(1): 54-56.

Low doses of prazosin potantiates the antinociceptive / analgesic effect of amitriptyline

Abstract

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