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Volume: 31  Issue: 3  Year: 2019
  The effects of intravenous dexketoprofen on postoperative analgesia and morphine consumption in patients undergoing abdominal hysterectomy [Ağrı]
Ağrı. 2010; 22(3): 98-102

The effects of intravenous dexketoprofen on postoperative analgesia and morphine consumption in patients undergoing abdominal hysterectomy

Sema Tuncer1, Ruhiye Reisli1, Melahat Keçecioğlu2, Atilla Erol2
1Departments Of Algology, Selcuk University Meram Faculty Of Medicine, Konya, Turkey
2Departments Of Anesthesiology And Reanimation, Selcuk University Meram Faculty Of Medicine, Konya, Turkey

Objectives: Dexketoprofen trometamol is a water-soluble salt of the dextrorotatory enantiomer of the nonsteroidal anti-inflammatory drug ketoprofen. The aim of this study was to investigate the effect of intravenous dexketoprofen on postoperative pain.
Methods: This study was performed on 50 (ASA I-II) patients scheduled for abdominal hysterectomy. Fifty patients were randomized into two equal groups. Patients received saline solution (Group I) or 50 mg intravenous dexketoprofen (Group II) 1 hour (h) before surgery and 8-16 h after surgery. All patients received a standard anesthetic protocol. At the end of surgery, all patients received intravenous (IV) morphine via a PCA (patient- controlled analgesia) device. Pain scores were assessed at 2, 6, 12 and 24 h after surgery. Morphine consumption and adverse effects were noted during the first 24 h after the surgery. The pain scores were significantly lower in the dexketoprofen group compared with the control group (p<0.05).
Results: The cumulative morphine consumption was also lower in the dexketoprofen group than the control group (p<0.05). No significant difference was observed in adverse effects between the groups (p>0.05).
Conclusion: We conclude that the administration of IV dexketoprofen provided a significant analgesic benefit and decreased the morphine requirements in patients undergoing abdominal hysterectomy.

Keywords: Abdominal hysterectomy, dexketoprofen; intravenous; morphine; postoperative pain.


Abdominal histerektomi uygulanan olgularda intravenöz deksketoprofenin postoperatif analjezi ve morfin tüketimine etkisi

Sema Tuncer1, Ruhiye Reisli1, Melahat Keçecioğlu2, Atilla Erol2
1Selçuk Üniversitesi Meram Tıp Fakültesi, Algoloji Bilim Dalı, Konya
2Selçuk Üniversitesi Meram Tıp Fakültesi, Anesteziyoloji Ve Reanimasyon Anabilim Dalı, Konya

Amaç: Deksketoprofen trometamol nonsteroid antiienflamatuvar bir ajan olan ketoprofenin aktif enantiomeridir. Bu çalışmada postoperatif analjezide intravenöz (iv) deksketoprofenin etkinliğini değerlendirmeyi amaçladık.
Gereç ve Yöntem: Abdominal histerektomi planlanan ASA I-II grubu 50 olgu çalışmaya alındı ve randomize olarak iki gruba ayrıldı. Operasyondan 1 saat önce ve operasyondan sonra 8. ve 16. saatlerde Grup I’e serum fizyolojik, Grup II’ye 50 mg deksketoprofen iv verildi. Bütün olgulara standart genel anestezi uygulandı. Cerrahinin sonunda olgulara iv hasta kontrollü analjezi cihazı ile morfin uygulandı. Ağrı skorları 2., 6., 12. ve 24. saatlerde değerlendirildi. Çalışma sonunda morfin tüketimi ve yan etkiler kaydedildi.
Bulgular: Ağrı skorları ve morfin tüketimi deksketoprofen grubunda daha düşük bulundu (p<0.05). Yan etkiler gruplar arasında benzer bulundu (p>0.05).
Sonuç: Sonuç olarak, abdominal histerektomi operasyonlarında iv deksketoprofen güvenilir ve etkin bir analjezi sağlamakta, morfin tüketimini azaltmaktadır.

Anahtar Kelimeler: Abdominal histerektomi, deksketoprofen; intravenöz; morfin; postoperatif ağrı.


Sema Tuncer, Ruhiye Reisli, Melahat Keçecioğlu, Atilla Erol. The effects of intravenous dexketoprofen on postoperative analgesia and morphine consumption in patients undergoing abdominal hysterectomy. Ağrı. 2010; 22(3): 98-102

Corresponding Author: Sema Tuncer, Türkiye


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